Accelerator mass spectrometry in biomedicine
A variety of complementary techniques have been used in connection with accelerator mass spectrometry in the field of biomedicine, facilitating extreme measurement capabilities. A number of new interdisciplinary research areas have subsequently been developed, with unique analytical capabilities. Examples are:
In pharmacology, we have demonstrated detection of 14C-marked drugs in human blood in the zeptomole level range (1 zeptomole=10-21 mole).
Microdosing (clinical phase 0 trials). New drug candidates can be administered directly to human subjects at an early stage to extract important pharmacokinetic data. This provides information on how the drug is absorbed, distributed, metabolized and excreted.
In a long term collaborative work with Karolinska Institutet we have developed a method to study specific cell types and extract neurogenesis rates for various parts of the human brain, previously not possible. See also The Human Regenerative Map.
In collaboration with the law authorities, date of birth and death can be determined for samples such as teeth from deceased individuals.
Dynamics of Cell Generation and Turnover in the Human Heart
Part of Cell, p. 1566-1575, 2015.
Dynamics of human adipose lipid turnover in health and metabolic disease
Part of Nature, p. 110-113, 2011.
Neurogenesis in the Striatum of the Adult Human Brain
Part of Cell, p. 1072-1083, 2014.
Dynamics of Hippocampal Neurogenesis in Adult Humans
Part of Cell, p. 1219-1227, 2013.
Carotid Plaque Age Is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin
Part of PLoS ONE, p. e18248-, 2011.
Accelerator mass spectrometry of ultra-small samples with applications in the biosciences
Part of Nuclear Instruments and Methods in Physics Research Section B, p. 97-103, 2013.
Stripline split-ring resonator with integrated optogalvanic sample cell
Part of Laser Physics Letters, p. 045701-, 2014.